Estradiol receptor has proteolytic activity that is responsible for its own transformation.
نویسندگان
چکیده
منابع مشابه
Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo
Elastic fibers are required for the elasticity and integrity of various organs. We and others previously showed that fibulin-5 (also called developing arteries and neural crest EGF-like [DANCE] or embryonic vascular EGF-like repeat-containing protein [EVEC]) is indispensable for elastogenesis by studying fibulin-5-deficient mice, which recapitulate human aging phenotypes caused by disorganized ...
متن کاملA urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity.
The role of urokinase-type plasminogen activator (uPA) and its receptor (uPAR/CD87) in cell migration and invasion is well substantiated. Recently, uPA has been shown to be essential in cell migration, since uPA-/- mice are greatly impaired in inflammatory cell recruitment. We have shown previously that the uPA-induced chemotaxis requires interaction with and modification of uPAR/CD87, which is...
متن کاملMatriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity
The type 2 transmembrane serine protease matriptase is involved in many pathophysiological processes probably via its enzymatic activity, which depends on the dynamic relationship between zymogen activation and protease inhibition. Matriptase shedding can prolong the life of enzymatically active matriptase and increase accessibility to substrates. We show here that matriptase shedding occurs vi...
متن کاملManaging an "own voice" problem that has an amplifier origin.
The complaint from hearing aid wearers of hollowness in the sound of their voice is typically associated with excessive low-frequency sound pressure level (SPL) in the ear canal. Increasing the vent diameter and/or reducing the gain in the low frequency would typically minimize this complaint. This paper reports on a case where the origin of hollowness was insufficient low-frequency gain compar...
متن کاملA Machine That Knows Its Own Code
We construct a machine that knows its own code, at the price of not knowing its own factivity.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1986
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.83.15.5367